He pointed to her being questioned for hours, from about 10 p.m. to 6 a.m. when she was exhausted.
"No food, no coffee, no bathroom breaks -- nothing," Moore said, adding that she was interrogated in Italian, which Knox did not speak fluently at the time. "She gave them a confused indictment of someone else … which she recanted after she got some food."
Knox's appeal is tentatively scheduled to begin Nov. 24. A new panel of two judges and six jurors from Perugia will reexamine Knox's case. A decision is expected by March.
Moore said he has no reason to believe he would be allowed to testify at the appeal or that Italian courts would be interested in anything an American had to say in her defense. But he's hoping Italian forensic experts convinced of Knox's evidence will pick up where he left off.
"The final court of appeal is going to be the press, the public," Moore said, charging that the public knows very little about how questionable the evidence against Knox really is.
In March, prosecutors filed an appeal seeking an even harsher sentence for Knox, who was ordered to serve 26 years in prison. The prosecutor is asking that she be sentenced to a life term. Knox's lawyers responded with an appeal in March, which asked for her conviction to be overturned.
Knox's appeal also called for an independent review of the DNA evidence, a request denied by a judge during her trial.
Knox has celebrated three birthdays, missed her college graduation and cut short her famous long locks while in prison. She passes time playing guitar at the prison mass, studying Italian and German and exercising during the one hour she can leave her cell.
"Amanda and I have now spent, her birthday and mine are a day apart, so we've spent the last three birthdays together," Knox's mother, Edda Mellas, told "Good Morning America." "We sing happy birthday for her. This year she got a lot of people. The guards and other inmates were singing to her."
But Mellas said the waiting is taking a toll on her daughter.
"The summer was hard, it's so hot [in the prison]. We tend to talk a lot about what she's doing to cope, but being locked up for a crime you didn't commit is devastating, it's almost unbearable, and she's having a tough time. But you know she's doing what she needs to do," she said.
Italian parliamentarian, Ricco Girlanda, who has said he is trying to soothe the diplomatic tensions that erupted during Knox's case, has visited Amanda in prison.
In more than 20 jailhouse conversations, Girland says Knox told him she one day hopes to adopt children and work as a writer. While Girlanda has not weighed in on Knox's guilt or innocence, he has penned a book about Knox to be released in October.