Today's hearing will address the trial's technical issues: whether journalists and cameras should be allowed in court -- some 140 journalists, photographers and TV crew members from 86 media organizations have requested access -- whether to allow objections presented by the various sides, and approval of the list of witnesses
The defense and the prosecution have requested more than 100 witnesses -- close to 90 each for the two defendants, and 88 for the prosecution, though many are expected to overlap.
Witnesses for Knox include Mellas, who was divorced from Knox's father when the suspect was a small girl. Mellas is expected to testify about the phone calls she had with Knox the morning Kercher's body was found, and as a character witness for her daughter.
"She's just an amazing young woman. She is so strong, she really believes that because she's innocent it'll all work out," Mellas said on "GMA."
The family shared some stories of the time they've spent with Knox since she's been held in Perugia.
"We only get an hour with her, so she wants to know what's going on with our lives," said Knox's sister, Deanna. "We get to talk to her, hold her hand, hug her, love her… it's sad when she leaves, too."
Guede is on the list of prosecutors Giuliano Mignini and Manuela Comodi, but because Guede was a co-defendant he can choose not to answer questions.
Kercher's parents and siblings, who are civil plaintiffs in the trial, will also be witnesses. Their lawyers want them to tell the court what Meredith was like and describe what they have been through since she was killed.
The trial will proceed with two hearings a week, and is expected to last at least until this summer.