Death Toll Rises to 250 in Baghdad Bombing, Officials Say

— -- The death toll following a bombing in Baghdad on Sunday has risen from 175 to 250, according to Iraq's Minister of Health. Another 200 people were injured in the attack.

The attack is the deadliest by a single suicide bomber since the U.S. invasion of Iraq in 2003.

The government minister largely responsible for security in Baghdad submitted his resignation Tuesday, The Associated Press reported.

The bombing occurred during the final week of the Muslim holy month of Ramadan. It bore the hallmarks of ISIS, according to The AP, and killed both Muslims and non-Muslims.

The attack on Baghdad followed a string of significant terrorist losses by ISIS on battlefields in Iraq and Syria, according to The AP. At the height of ISIS' power in 2014, it controlled nearly a third of territory in Iraq and Syria, The AP reported.

Coalition airstrikes since then have cleared the way for ground forces in Iraq and Syria to regain territory.

ABC News' Mazin Faiq contributed to this report.