David Petraeus Affair: FBI Probe Into Inbox of Paula Broadwell Uncovers 'Human Drama'

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"We all will make mistakes. The key is to recognize them and admit them, to learn from them, and to take off the rear-view mirrors -- drive on and avoid making them again," he said.

Flashback: Martha Raddatz profiled David Petraeus when he retired from the military. Watch that here.

The departure of Petraeus will add another hole to Obama's leadership team, which is expected to lose some high-profile faces in the coming weeks and months. Secretary of State Hillary Clinton is among the cabinet members who have said they will not stay in the administration for a second term. A hole at CIA will add yet another position that requires Senate confirmation to that list.

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