Coming Up on 'This Week': Rep. Paul Ryan and White House Chief of Staff Denis McDonough

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House Budget Committee chair and former 2012 Republican vice presidential candidate Rep. Paul Ryan, R-Wisc., gives his response to President Obama's State of the Union address, in a "This Week" Sunday exclusive.

Plus, newly-appointed White House Chief of Staff Denis McDonough discusses the roadblocks facing President Obama's second term agenda, Sunday on "This Week."

Will the looming battle over budget cuts overshadow the president's State of the Union appeals on gun control, immigration reform, and raising the minimum wage? Can House Republicans work with the White House on those key issues, or will gridlock continue? And who will be the face of the Republican party as it tries to re-boot its image?

Rep. Paul Ryan and White House Chief of Staff Denis McDonough speak to ABC News Chief White House Correspondent Jonathan Karl, Sunday on "This Week."

Then, the powerhouse roundtable debates all the week's politics, with ABC News' George Will; Rep. JoaquĆ­n Castro, D-Texas; Former House Speaker and 2012 Republican presidential candidate Newt Gingrich; Washington Post columnist Ruth Marcus; and Romney 2012 campaign senior adviser Stuart Stevens.

And in this week's Sunday Spotlight, Dr. Ben Carson, Director of Pediatric Neurosurgery at Johns Hopkins, gives his diagnosis for the current state of our union and discusses his recent remarks at the National Prayer Breakfast.

See the whole political picture, Sunday on "This Week with George Stephanopoulos."