The current majority whip, Rep. James Clyburn, D-S.C., also said this afternoon that he will run for minority whip, creating a potentially ugly battle for the House Democrats' second-ranking leadership post in the minority.
"I am seeking your support and vote for Democratic whip," Clyburn wrote to House Democrats. "Throughout the course of my tenure, I have demonstrated the ability and willingness to give selfless service to our Caucus. My record of leadership in our Caucus has prepared me well for the challenges ahead.
"I am confident we can rebuild the coalition that carried Democrats and President Obama into office in 2008 and that it will lead us on the road back to the majority in 2012."
Some Republicans predicted that if Pelosi is successful in her run for minority leader, it will lead to more House Democrats' losing in the 2012 elections.
"Given that there are now 60-plus defeated Democrat House members urgently seeking jobs due to Nancy Pelosi's failed leadership, we welcome her decision to run for House minority leader based on her proven ability to create jobs for Republican lawmakers," Ken Spain, communications director at the National Republican Congressional Committee, said.
"The definition of insanity is doing the same thing over and over again, and expecting a different result. Of course, if House Democrats are willing to sacrifice more of their members in 2012 for the glory of Nancy Pelosi, we are happy to oblige them."