When asked why people should listen to him, or other celebrities, just because they're famous, he said: "I don't know that we should ... I don't believe people should listen to me. I'm hoping the images ... will speak for themselves."
Despite the turmoil of the past year, Pitt insists it has been a good one for him.
"New chapter," he said "Truly a really interesting time -- it's a shake-up year ... a blossoming year ... a year of re-direction and I find it very, very interesting."
He added: "Listen, everything, you know, has a cost. Every decision that's made and every choice in life ... I make my choices and I live with those. I like that. I like that. My mistakes are my mistakes. My wins are my wins ... that I can live with."
He also said he maintains his dream to have children. "The dreams don't change, the dreams become more vivid," he said.
Images of Pitt interacting with children in Africa raise the question: would he ever consider adopting?
"I don't know. I'm certainly open to it," he said. "I think it's a beautiful idea ... especially meeting these kids firsthand, but at this point, I don't know."
When asked about family and his future, Pitt said, it "just feels like a natural progression," he said. "And, you know, anything to get the focus off myself. It's gotta be a healthy thing."
Pitt is working with The ONE Campaign, a new effort to rally Americans to fight the emergency of global AIDS and extreme poverty.