Ohio State confirmed the news on Tuesday afternoon after ESPN's Brett McMurphy and other media outlets reported earlier that Miller's injury would end his season. Miller had an MRI on his throwing shoulder in the morning.
"I'm not sure that America really understands the time, the training," Ohio State coach Urban Meyer told ESPN Radio's "Mike & Mike" on Wednesday morning. "You train hours upon hours upon hours. So you just see a guy that's like a member of your family go down and you're like, 'Ugh.' Your gut starts to hurt. You go over to see if he's OK. It was a tough situation."
Widely tabbed as a Heisman Trophy contender this preseason, Miller suffered the injury during a noncontact portion of practice just hours after the senior declared himself 100 percent healthy following offseason surgery to the shoulder.
Miller threw for 2,094 yards and 24 touchdowns and ran for 12 more scores in leading the Buckeyes to the Discover Orange Bowl last season.
Ranked fifth in the preseason Associated Press poll released Sunday, Ohio State is expected to be in the national title conversation.
"I told our offensive coaches that we lost a hundred yards of offense, so let's figure out how to find a hundred yards of offense that Braxton gave us every game, on his own. So we have to do that," Meyer told "Mike and Mike."
"The good thing is that when you look to your right, look to your left, it's kind of exciting. If I'm a young player, that's four more touches that I get now. We're taking the opposite approach: We're not worried about November, we're worried about tomorrow."
The reigning two-time Big Ten Offensive Player of the Year, Miller first hurt the shoulder in the Orange Bowl. He had surgery that prevented him from contact in spring practice and was held out of several practices and scrimmages in August.
"I love Ohio State and Buckeye nation, and my goal is to come back from this injury stronger and better than ever," said Miller, who has yet to take a redshirt season. "I am on course to graduate in December and I want to attend graduate school, and then return to lead the Buckeyes next season .
"In the meantime, I want to give all the support I can to my coaches and teammates as they chase a championship this season."
Miller did not practice this spring and had been limited by athletic trainers and coaches in the number of throws he was making this fall.
Redshirt freshman J.T. Barrett is expected to be the starter when the Buckeyes open the season Aug. 30 against Navy in Baltimore. Meyer said Saturday that redshirt sophomore Cardale Jones is the third-team quarterback.
"Our guys have responded," Meyer told ESPN Radio. "The best thing about everything has been Braxton's reaction. He's got a big smile on his face, he comes out to practice, talking to our quarterbacks. He's a grown man."
Miller is one of the Big Ten's most decorated quarterbacks, and the falloff in experience to Barrett and Jones is huge.