The Nets confirmed Saturday that Lopez fractured the fifth metatarsal of his surgically repaired right foot, which he fractured in 2011 and later had a screw replaced in.
The team announced Saturday in a statement that Lopez's status will be updated next week after a consultation with team physicians. But according to league sources, Lopez will miss the remainder of the season due to his ailing health and the Nets are operating as so.
The injury was earlier reported by Comcast SportsNet New England.
The 7-foot center suffered the injury sometime in the second half Friday night, possibly in the third quarter, during the Nets' overtime loss to the Philadelphia 76ers, a league source said.
Lopez gutted his way through the injury, playing 44 minutes while making 9-of-19 shots and finishing with 22 points and seven rebounds. The Nets discovered the bad news after the game when Lopez underwent X-rays on his troublesome foot.
The Nets (9-17) have been ravaged by injuries in this slow start to the season despite coming in with championship expectations.
The Lopez season-ending injury, though, would appear to be the biggest blow for the Nets. Lopez was averaging 20.7 points and six rebounds.
Lopez gave rookie coach Jason Kidd an advantage over several other teams inside the paint with a young, high-scoring big man.