But the Penguins finally caught up to the game, and the result was a 4-3 victory over the plucky Columbus Blue Jackets.
Now it falls to a Columbus team that is new to the business of playoff hockey to ensure it doesn't end up chasing the entire series against the more talented, more experienced Penguins.
In spite of trailing 1-0 and 3-1, the Penguins rallied for the win on a hard Brandon Sutter wrist shot midway through the third period. It was the only time in the game the Penguins led, which is kind of how the playoffs work if you're good.
The victory ended the Penguins' four-game playoff losing streak dating back to last year's Eastern Conference final against the Bruins, when they were swept, scoring just two goals in a series loss that in some ways still hangs over this team.
For much of Wednesday's Eastern Conference quarterfinal opener, you wondered whether the streak would go to five.
The Blue Jackets used their speed and took advantage of Pittsburgh's miscues to score first, with Jack Johnson jumping into the play and putting home a nice Brandon Dubinsky pass before the first period reached the midpoint.
After the Penguins knotted the game at 1-1, the Blue Jackets opened up a two-goal lead with a goal late in the first and another early in the second, a short-handed marker by Derek MacKenzie.
For a moment, all of the wondering about the Penguins' psyche, the questioning of whether they are still a Cup contender in spite of their talent and the thinking that they were missing some crucial part of their former championship DNA bubbled to the surface.
The sold-out Consol Energy Center was stunned into silence.
"It was good for everyone to stick with it," Pittsburgh captain Sidney Crosby said.
"It felt like we probably had more chances in the second half," he added. "I don't feel like [we] sat back at 3-3. I thought we generated some good chances.
"I think those two goals that quickly [to tie the game at 3-3] really allowed us to kind of get settled and really play the rest of the game the way we wanted to."
The storylines in this series have been clearly identified.
Where are the Penguins five years after winning the Stanley Cup in 2009? Is some sort of window closing on this talented squad?
On the other side of the ice, what kind of challenge can the Blue Jackets mount as they take part in in the playoffs for just the second time in franchise history with a largely inexperienced squad that included 11 players on Wednesday night taking part in their first NHL playoff game?
"They've [Penguins] been through this. That's a team that's won over there. They answered on their power play. Their power play's been good for them all year. It gave them life. It got them back in the hockey game," said former Penguin Mark Letestu, who was traded to Columbus in the fall of 2011.