Broncos coach John Fox acknowledged Monday that Welker's health was "what we're thinking about," saying that the five-time Pro Bowler would undergo the NFL's concussion protocol.
Welker sustained his most recent concussion in last Sunday's victory over the Tennessee Titans.
According to the league's protocol, any player who suffers a concussion is not permitted to participate in a full practice until the following Friday at the earliest.
Welker, the Broncos' second-leading receiver this season, also suffered a concussion against the Kansas City Chiefs on Nov. 17. The 10-year veteran returned the following week to play against his former team, the New England Patriots.