Suryia the orangutan and Roscoe the Bluetick Coonhound met in a sanctuary for endangered animals two years ago, in South Carolina, according to the U.K.'s Daily Mail.
Roscoe was an underfed stray, but Suryia quickly took him under his wing.
Dr. Bhagavan Antle, founder of The Institute of Greatly Endangered and Rare Species (TIGERS) in Myrtle Beach, told the Daily Mail that Roscoe followed him and Suryia through the park's gate one day.
"As soon as he saw Roscoe, Suryia ran over to him and they started playing," Antle said "It was unusual because dogs are usually scared of primates; but they took to each other straight away."
After a few unsuccessful phone calls to find an owner, Antle said they decided to let Roscoe stay.
Now the the pair have a ball frolicking around the park. "They will spend a few hours each day together rolling around, swimming," Antle said. "Suryia will take Roscoe for walks around the enclosure and even feeds him some of his monkey biscuits."
The pair may even appear soon on Oprah Winfrey's show, the Daily Mail reported.
But these two aren't the only amazing animals ABCNews.com has encountered recently.
Here are 11 more of our favorites.
Even some humans can't do it. But Ujian, a 14-year-old ape at Germany's Heidelberg Zoo, is such an accomplished whistler, he just cut his first CD. He reportedly taught himself how to whistle last summer.
"Ich Bin Ujian" ("I Am Ujian") will go on sale at the zoo in June, Germany's Der Spiegel reported earlier this week. The fun, pop-rock song with a bit of a reggae influence, combine's Ujian's whistling with lyrics sung by Tobias Kämmerer.
The chorus includes the lines: "I am Ujian the orangutan. I am so cool, man, I'm a star."
In the YouTube universe, this bird is a big star. A video of Snowball rocking out to the Backstreet Boys has been viewed more than 2 million times since it was posted in 2007.
The video also inspired a first-ever study on how animals "dance" to the music that was published by the journal Current Biology in late April.
The article said that the animals shared with people some ability mimic sounds they hear, the Associated Press reported.
Call her the Nadya Suleman of the canine world. A super-fertile Florida dog named Dixie gave birth to 20 puppies last week.
"It's been around-the-clock feedings" said Dixie's owner, Deanna Stewart. "Because she has so many, she can't do it on her own, so we're having to bottle feed just to make sure they're all rotated and everything's fine with that."
Dixie fell just short of the world record, which is 24 puppies. But her owners have their hands full.
"It's a hard job. We have to go every three hours and feed them," said Deanna's son, Braxton Stewart.
Her work isn't for sale yet, but an African elephant at a British safari park already has more than 50 paintings in her portfolio.
Five, a 16-year-old elephant at the West Midland Safari Park in Bewdley, Worcestershire, first demonstrated her penchant for painting when zookeepers left a paintbrush in her enclosure one day, the BBC reported.
She picked up the brush and appeared to be painting.
Now, when her keeper says, "paint," Five picks up the brush. And she puts it down when she is told, "Okay."