Will Your Lifestyle Hurt Your Grandchildren?
Scientists find visible evidence some scars can be passed on.
— -- Laura Gaydos couldn't believe her own eyes. Excited but unsure, she pulled other people into the lab on the campus of the University of California, Santa Cruz, to see if they could see what she thought she had just seen.
They could.
What they saw was the first visual confirmation of one of the most fundamental tenets of a new field that is revolutionizing the world of biology. The powerful microscope revealed clear evidence that scars from environmental stresses can be passed on from one generation to the next and probably to many generations that follow.
It didn't change the DNA, but it changed how the DNA was regulated, and that was a big step forward in the field of epigenetics.
In the past couple of decades researchers in labs around the world have compiled epigenetic evidence that the so-called blueprint for life -- the rigid collection of genes and chromosomes and cells that are supposed to define us -- isn't as rigid as we had thought.
Epigenetics is sort of like software running the DNA hardware, determining which genes are expressed and which are repressed, or simply turned on or off.
DNA is still quite clearly the 500-pound gorilla in the room, but there's a new player that has some control over the beast. It is expected to open new avenues for medical treatment, including the prevention of cancer, and it could explain some scientific mysteries that have baffled experts for generations.
The microscope showed that what scientists call an epigenetic mark, an environmental memory of famine, abuse, exposure to toxic substances, or even less than nutritious meals, can be passed from one cell to new cells formed during DNA replication in the critical early stage of building an embryo.
Some scientists have argued that the scar would be so diluted as it spread into thousands of cells that it would have no effect on whatever the embryo eventually became, whether it was a worm or a human.But the Santa Cruz researchers watched the show through five cell divisions, and the mark never dimmed.
"What's so compelling is the evidence is very visual." Susan Strome, coauthor with Gaydos of a study published in the journal Science, said in a telephone interview.
"It's really a dramatic display of this passage" from one generation to the next, she said.
Strome's lab was able to pull it off because the lab is equipped to manipulate both the sperm and the egg as they combine to start the embryonic process. They could add an enzyme, for example, to see how that effected the transmission of the mark.
"We could control what we allowed dad to contribute, and we could control what we allowed mom to contribute," added Strome, professor of molecular, cell and development biology at UC Santa Cruz. "That was really the key."
For this experiment, dad and mom were roundworms, C. elegans, a tiny workhorse in labs around the world. For obvious reasons they couldn't do the same experiment with humans. But do the findings apply to more complex organisms, like us?
"I think the answer is definitely yes," she said. "We all have similar genetic material, humans, mice, fruit flies, all the multicellular organisms I know of. I think all of these organisms will show something similar to what we documented."
A scientist at the National Cancer Institute has described the research as "quite remarkable."
Scientists are studying a broad range of issues from diabetes to mental health for links to epigenetics.
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