"I think there is potential there. That would be potentially complicated by a group of people protesting," Pistole said. "If there are no protests, then obviously we'll have just the normal crush of holiday travelers."
Though thousands of Facebook users have said they've vowed to opt out, some say the movement may be overstated and overblown.
"The truth is, most travelers just want to get to their destination as fast as possible," said Genevieve Shaw Brown, senior editor at Travelocity.
Across the nation, there are 385 of the new, full-body scanners at airports, but there are a total of 2,100 security lanes.
That means about 80 percent of security lanes won't have the machines in place.
"Most people will go through business as usual. The metal detector that we've all become used to, taking off the shoes, pouring our liquids in to the tiny little containers, business as usual for the vast majority of people," Brown said.
ABC News' Kevin Dolak and Ryan Creed contributed to this report.