George Anthony believes his daughter, Casey Anthony, drugged his granddaughter, Caylee, to sedate the toddler so her mother could go out.
"Yeah I blame my daughter for Caylee not being here today," George Anthony said on the "Dr Phil" show. "I believe she was there and I also believe she probably had some help."
In the strongest accusation he has made against his daughter, an emotional George Anthony told Phil McGraw that he believes Casey Anthony used drugs to act as a chemical babysitter for 2-year-old Caylee so that she could party with friends.
Casey Anthony was acquitted of murder charges this summer after she claimed at her trial that Caylee accidentally drowned in the family pool.
"Inside of my heart, I don't believe that Caylee drowned…I believe there's something else that happened to her…I believe that Casey or someone else that she was with possibly gave too much [drugs] to Caylee...she fell asleep and didn't wake up," George Anthony said, smoldering with anger.
Casey Anthony's Father Blames Her for 'Caylee Not Being Here'
The reason for the alleged drugging was "to go out and have a good time, go out with friends... to have this life that she didn't have with Caylee…some freedom that she wanted, that's what I feel," he said.
Referring to the "smell of death" that was in his daughter's car, George Anthony added, "Do I believe that she was possibly in the back of the car? I do…and she was placed down there at the end of our street."
George Anthony's claims about his daughter's role in Caylee's murder shocked wife Cindy Anthony.
"This is the first time you ever said that to me... I'm really kind of shocked to hear that today," Cindy Anthony told her husband.
George Anthony said that he doesn't accept the drowning story because of the way Caylee's remains were found on Dec. 11, 2008. Caylee's skeletal remains were found with duct tape over the mouth and nose and had been stuffed into trash and laundry bags.
"If this scenario that Casey had told to her defense about Caylee drowning [were true] why go through all this elaborate stuff-- to tape her up, to put her in a laundry bag, put her in a trash bag?" he asked.
Cindy Anthony, however, said she believes her daughter's claims that Caylee accidentally drowned.
"I buy the part that Caylee drowned," she said.
Cindy Anthony also said that the acquittal of her daughter is the right verdict.
"I prayed to God for three years to find out what happened to Caylee … I got my answer that it was an accident ," she said.
"I believe justice for Caylee was when her mother walked because I know the love that those two had and I know Caylee's soul would never have rested knowing her mother had been vilified for her death," Cindy Anthony said.
Cindy Anthony, while believing Caylee drowned, also believes her daughter had something to do with the disposal of the toddler's remains. She told McGraw that Casey may have hid the truth about Caylee's whereabouts to protect a possible accomplice.
"I know Casey knows where Caylee was placed. I know in my heart that now...I'm not sure if she put her there by herself or if someone helped her," she said.
Cindy Anthony gave a possible reason why Casey Anthony could allow her daughter's remains to be treated so cruelly.
"I know that Casey's belief is that as soon as someone dies, they leave their body and that's no longer Caylee...Caylee went straight to heaven," she said.