Holmes, 35, and the "Top Gun" actor, 52, were married from 2006 to 2012 and even have daughter Suri together.
Now, the "Dawson's Creek" actress says she has moved on from all the attention she got from the split and wants to keep that in the past.
"I don't want that moment in my life to define me, to be who I am," she told People magazine for this week's cover story. "I don't want that to be what I'm known as. I was an actor before, an actor during and an actor now."
As for how she lives her life, Holmes added, "I don't have any fear now, I don't have a lot of rules for myself, and I don't take myself that seriously."
Holmes also opened up about being a single mother to her 8-year-old daughter, who gets a lot of attention herself at such a young age.
"I'm learning every day, and I have been since the minute I became a mom," she said, adding Suri "means everything to me."