Beau Biden, the former attorney general of Delaware, passed away at the age of 46 after a battle with brain cancer.
"For the Bidens, being there for each other was and is everything. Any real conversation with Joe was about family and how much he and Jill loved their children and grandchildren."
President Obama, along with the first lady, visited the Bidens at the Naval Observatory to share their condolences in person today.
He also weighed in shortly after the announcement of Beau Biden's death, saying the Obama family was "grieving" for the Biden's loss.
"Beau Biden believed the best of us all. For him, and for his family, we swing our lanterns higher," the president said. "Michelle and I humbly pray for the good Lord to watch over Beau Biden, and to protect and comfort his family here on Earth."
Democrats and Republicans alike released statements and tweeted condolences and remembrances to the Biden family.
"His life was so rich and it is unspeakably sad to see him leave us far too soon. Beau's dedication to public service was deep, broad and profound. He embodied the best and most noble traits that his parents sought to instill in him," Reid said in a statement. "I know Joe is very proud and he should be proud because Beau was simply a joy to know."
"Throughout his life, Beau never shied away from doing the right thing, even when it meant doing the hard thing. Beau served his country and community with honor, and that's how he will be remembered," Coons said. "My family knew Beau as a family man devoted to his wife, Hallie, and their children, Natalie and Hunter, and as a hardworking, kind-hearted person."
ABC News' Erin Dooley contributed to this report.