"For many Americans, this is still a time of deep uncertainty. I have one friend, just weeks ago, she was making millions of dollars a year, and she's now living out of a van in Iowa," joked Obama, referencing presidential candidate and former Secretary of State Hillary Clinton.
Using host Cecily Strong to poke fun at CNN, Obama joked, "On Saturday Night Live, Cecily impersonates CNN anchor Brooke Bolden, which is surprising because usually the only people impersonating journalists are journalists on CNN."
Taking on Indiana's "Religious Freedom" law Obama brought up his close friendship with Vice President Joe Biden, "We've gotten so close, at some places in Indiana, they won't serve us pizza anymore."
On former Vice President Dick Cheney, Obama said, "He thinks I’m the worst president of his lifetime, which is interesting because I think Dick Cheney is the worst president of my lifetime."
Make sure to check out some of the commander-in-chief's best lines in the video above.