Marshalltown, Iowa, suffered major damage, including to its police department and City Hall, while the Vermeer Plant in Pella took a direct hit from an apparent tornado.
"Devastated to see the destruction from today's severe storms & tornadoes," Iowa Gov. Kim Reynolds tweeted. "Praying for all Iowans impacted & for the emergency management crews responding tonight."
The governor is set to tour damaged towns Friday.
Since the severe weather outbreak began Wednesday, there have also been two reported tornadoes in South Dakota and a reported tornado in Minnesota.
The National Weather Service will be conducting storm surveys Friday to confirm these tornadoes and issue an intensity rating.
Friday marks the third day of the multiday severe weather outbreak.
Over 35 million Americans are at risk for severe weather Friday, which is expected to be concentrated in the South and Midwest, including major cities like Birmingham, Alabama; Nashville, Tennessee; Louisville, Kentucky; Indianapolis and Detroit.
Storms are expected to fire up in the Ohio and Mississippi River valleys Friday afternoon and evening, and any slow moving storms could produce flash flooding.