Lee County, which encompasses Fort Myers, accounts for most of the fatalities.
The remnants of Ian are charging up the East Coast on Saturday after making landfall as a Category 1 hurricane in South Carolina on Friday afternoon.
The monster storm made its first U.S. landfall on Wednesday on Florida's west coast as a powerful Category 4 hurricane, shredding homes with ferocious winds topping 150 mph. Florida's death toll has climbed to at least 81, according to information from local officials.
More than 1,100 Floridians have been rescued by the Florida National Guard in the wake of Hurricane Ian, according to state officials.
The rescues include 1,076 people evacuated from flooded areas in southwest and central Florida as of Saturday morning, as well as 78 people transported from a flooded nursing home facility, Gov. Ron DeSantis' office said in a press release.
The Florida Department of Transportation announced Saturday that it is reopening the 14-mile stretch of Interstate 75 that was shut down due to rising river water under the highway. Officials said the Myakka River's water levels had receded enough to safely reopen the highway.
But, officials warned they may have to shut down the interstate again if water levels rise once more.
Officials had shut down I-75 from mile marker 179, near North Port and Toledo Blade Blvd. to mile marker 193, near Jacaranda Blvd, and long detours were in place.
I-75 is the main highway on the west coast of Florida and is a main route for travelers between Tampa-St. Petersburg and Fort Myers and Naples.
The Centers for Disease Control and Prevention put out a health advisory to healthcare professionals treating patients in areas affected by Hurricanes Fiona or Ian, telling them to maintain a high index of suspicion for carbon monoxide poisoning.
"Other people who may have been exposed to the same CO source may need to be identified and evaluated," the CDC said in a health advisory.
-ABC News' Eric Strauss
Four people have died in North Carolina since Friday in storm-related incidents, state officials said Saturday.
Two people died due to car accidents caused by storm conditions, one man drowned in his car and a fourth man died due to carbon monoxide poisoning from a generator.
Among those killed was a 25-year-old man who lost control of his vehicle and hydroplaned into another vehicle, a 24-year-old woman whose vehicle went off a wet road and struck a tree and a 22-year-old man who drowned when his truck left the roadway and submerged in a flooded swamp.
A 65-year-old man died Saturday from carbon monoxide poisoning from a generator running in his closed garage while the power was out. His wife was hospitalized.
“The storm has passed, but many hazards remain with downed trees, downed power lines and power outages,” said North Carolina Gov. Roy Cooper in a press release. “We mourn with the families of those who have died and urge everyone to be cautious while cleaning up to avoid more deaths or injuries.”
