It's a move that would've been unthinkable for Rev. Eric Camden. Stephen Collins, the former star of "7th Heaven," has filed for divorce from his wife, Faye Grant.
Collins, 64, said in statement that Grant has been "my dearest friend and a loving mother" to their daughter Kate. He said the two "are moving forward separately in our lives" and "I know that we'll go through this process in a way that honors our family."
Grant told E! News she was "devastated" by Collins' surprise divorce filing. "I wish him the very best in whatever path he chooses to take," she said. "Twenty-seven years of marriage in Hollywood is the equivalent of 189 dog years. I was exhausted."
Grant did not immediately respond to ABCNews.com's requests for comment.
Collins isn't alone in starting a new chapter. In the nearly five years since "7th Heaven," TV's longest running family drama, went off the air, much has changed for many of the show's original cast:
"7th Heaven" launched Biel's career almost into, well, the heavens. While she was on the show, Biel branched out to get away from the good-girl image of her character, Mary Camden. She posed topless in the March 2000 issue of Gear magazine, a move that led "7th Heaven's" producers to make Mary more rebellious and eventually write Biel off the show (though she returned for pivotal episodes, including the series finale).
Biel, now 30, is still known for having one of the most enviable bodies in Hollywood. She's also starred in critically acclaimed fare like "Easy Virtue" with Kristin Scott Thomas and Colin Firth, and more commercial stuff like "New Year's Eve." And with wedding watch on for her and fiance Justin Timberlake, it's likely you'll be seeing a lot of her in the coming months.
The erstwhile Matt Camden hopped around a few other TV shows after "7th Heaven's" end, including ABC's "What About Brian" and "Samantha Who?" His family life has been decidedly un-Camden like. Watson, 38, has been married twice and has two sons from his second marriage to Tracy Hutson of "Extreme Makeover: Home Edition." In May, a rep for Watson announced that he's expecting another child with Natasha Gregson Wagner, the daughter of the late actress Natalie Wood and film producer Richard Gregson. (Richard Wagner is her stepfather.)
Since leaving behind the part of the smiling yet often harried mom Annie Camden, Hicks, 60, has become a TV movie staple, appearing in Lifetime's "Stranger with My Face," "Poison Ivy: The Secret Society," and "Borderline Murder." She's been praised for her independent film and theater work, including the movie "My Name Is Jerry" and the Las Vegas production of the Moss Hart play "Light Up the Sky."
True story: Mitchell originally auditioned to be Mary Camden, but was turned down by producers. When she read for the part of rebellious younger sister Lucy, though, she won them over. As the show wound down, she made new career moves, joining the cast of 2005's "Saw II" and putting out a self-titled debut country album in 2006. She married accountant Michael Cameron in 2008. Her "7th Heaven" sisters Jessica Biel and Mackenzie Rosman attended and Biel served as a bridesmaid, according to People magazine.
Like Jessica Biel, Gallagher left "7th Heaven" early. He left in 2003 during the show's eighth season to attend college at the University of Southern California full time, but came back to the show on a part time basis in following seasons. Since "7th Heaven" ended, Gallagher, 27, has landed a number of gigs on other dramas, including "Saving Grace," "Bones," "Without a Trace," and "The Vampire Diaries." He's also a public supporter of the organization Cure Autism Now; his half-brother Killian was diagnosed with autism at age 3.
Rosman was only seven years old when she began playing Ruthie Camden on "7th Heaven." She started branching out while the show was still running, memorably playing pageant queen JonBenet Ramsey in "Getting Away with Murder: The JonBenet Ramsey Mystery." Since the end of the show, the 22-year-old actress has appeared on "The Secret Life of the American Teenager" and the Edgar Allan Poe fantasy film "Fading of the Cries." She's an activist for the Cystic Fibrosis Foundation in memory of her stepsister, who died due to complications from the disease in 2008.