Aniston recently teamed up with Cox for the season premiere of "Cougar Town." Now that they're both single, maybe they'll be spending time together off-set too.
In 2006, after his ill-fated "Friends" spin-off "Joey" was cancelled, LeBlanc had few callers -- both of the professional and the personal kind.
His marriage to British model Melissa McKnight failed around the time "Joey" did. According to People magazine, the couple had trouble with their daughter, Marina, who suffered seizures from shortly after birth until she was two years old. As the couple's third anniversary approached, LeBlanc suddenly moved out and began seeing his "Joey" co-star Andrea Anders. LeBlanc, 43, also got some not-so-helpful tabloid inches after he admitted to groping a stripper at a Canadian nightclub.
Perry, 41, has struggled to find his groove since playing Chandler on "Friends." His attempts to repeat his sitcom success on the small screen have mostly fallen flat. Perry's 2006 series, "Studio 60 on the Sunset Strip," was dropped by NBC after the first season because of poor ratings. Last year, he tried again to return to television as a radio talk show host in "The End of Steve," but the dark comedy was scrapped after one episode. His latest hope: playing a selfish jerk in the upcoming ABC series "Mr. Sunshine," due to debut in 2011.
Perry hasn't had better luck on the big screen. In his first film role after "Friends," Perry played a chronically depressed man in the 2007 movie "Numb." The film flopped at the box office. His most recent role in "17 Again" was better received, but he played second string to the flim's star, Zac Efron.
In the past, Perry has admitted to struggles with depression, alcohol and prescription drug addiction. Production on 2002's "Serving Sara" had to be shut down for three months while Perry checked into rehab.
"Your consciousness has to change and, I was very lucky and smart enough to realize that at that moment, it was life and death time, and movies, acting, dating, sports and everything just have to take a sideline to this," he told Film Monthly at the time.
Through it all, he's remained chronically single (save for a two-year-long relationship with former fashion student Rachel Dunn), and he doesn't know why.
"People sometimes ask me how I've managed to get to the age of 39 and never been married. The answer is, I don't know," Britain's Daily Mail quoted Perry as saying in 2009. "I'm hoping that will change. I'm a pretty happy guy, who is looking for someone who enjoys having a good time. I'm hoping it will all work out for me in the end."
Kudrow's managed a feat none of the other "Friends" women seem to have: finding success both on set and at home.
Since hanging up Phoebe Buffay's tie-died ensembles, Kudrow, 47, has attached her name to a variety of successful movies, including "Analyze This" and its sequel, "P.S. I Love You," and "Easy A." She's currently starring in the online series "Web Therapy." And like Aniston, she made an appearance on Cox's "Cougar Town."
In 1995, Kudrow became the first of the "Friends" cast to marry, and her relationship with her husband, French advertising executive Michel Stern, still seems solid. The two have a 12-year-old son, Julian Murray.