Five Potential Replacements for the Irreplaceable Oprah Winfrey

Wanted: one host -- scratch that -- one larger-than-life personality to helm a culturally iconic TV show that serves as a stomping ground for the most recognizable celebrities, politicians, and newsmakers in the world. Must offer a shoulder to cry on as well as a couch to jump on. A bellowing voice: a bonus.

Oprah Winfrey's vacating that gig in mere months (September 2011, to be exact, though she'll still dabble in TV through OWN, her cable network, and other projects).

It's time for Winfrey's would-be successors to fix up their resumes and get in the game. Below, check out five people who could take over her throne. Of course, some candidates might be more viable than others, but when it comes to crowning the next talk show mogul, it never hurts to cast the net far and wide.

VIDEO: The comedian announces a 2011 launch for her syndicated talk show.
Rosie O'Donnell's Talk Show Return

Rosie ODonnell

Rosie O'Donnell

Maybe she yearns for the spotlight, maybe she's getting nostalgic about those bouts with Elisabeth Hasselbeck, or maybe she just misses the VIP treatment at suburban theme restaurants -- whatever the case, Rosie O'Donnell is determined to return to TV and take over "Oprah's" audience.

VIDEO: Oprah to End Reign as Queen of Talk

"I gotta get back on TV," she reportedly told New York Post columnist Cindy Adams recently. "There's a Chuck E. Cheese near where I live. I've been taking the kids there for years. And they know I tip 100 percent because I used to be a waitress. Would you believe the other day, for the first time, they made me wait. On a line. Behind a rope. I gotta get back on TV. ... And it'll be in Oprah's time slot."

Them's fighting words. O'Donnell has also teamed up with producers Dick Robertson and Scott Carlin, both versed in syndicating TV series, to help her plot her fall 2011 return to the small screen. "This is a once-in-25-years opportunity," Robertson told the New York Times Monday. "There is this gaping hole starting in September of 2011 when Oprah goes away. Who better to fill it than Rosie?"

TV is familiar turf for the comedian: her last solo talk show, "The Rosie O'Donnell Show," ran from 1996 to 2002 and won a slew of daytime Emmys. But her more recent stint on daytime television was marked by squabbles, not statues. Helming the coffee table of "The View" from 2005 to 2007, O'Donnell sparked memorable on-air spats with Donald Trump and fellow "View" co-host Hasselbeck. Viewers tuned in for verbal sparring, which isn't what usually draws "Oprah's" masses to the tube. Chance of taking over O territory: 7 out of 10.

Ellen DeGeneres

Ellen DeGeneres

She can talk, she can joke, she can dance, she can sing (or at least, judge singing). Is there anything Ellen DeGeneres can't do? The host of "The Ellen DeGeneres Show," now also an "American Idol" judge, continues to charm audiences and the industry with her ease on all types of TV (not only does she have those two shows to her name, she also has the '90s sitcom "Ellen" and Oscar and Emmy hosting gigs under her belt). And like Winfrey, DeGeneres is passionate about causes: she just gave a lesbian high school student who was banned from bringing her girlfriend to the prom a $30,000 scholarship. Chance of taking over O territory: 9 out of 10.

Rachael Ray

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