The ghost-face killer is back, and with him, another round of panting, slashing, and blood-curdling shrieks galore.
Like the "Screams" that came before it, much of the latest movie has been kept under wraps. On set, director Wes Craven took steps to ensure that the cast didn't divulge details of the plot with tweets and texts.
"We took everyone's cell phones," Craven told The Associated Press. "We made them sign non-disclosure agreements, and we went on the Internet and watched all night to see who posted what. ... By and large, people honored our plea to keep it a secret."
Internet leaks were something Craven probably worried less about in 1996, when the first installment of the slasher-film franchise came out.
What's the cast of the original "Scream" up to now? ABCNews.com takes a look at what they're doing, below:
Courteney Cox. When Cox, 46, first appeared in "Scream," she was best known as Monica Geller, the neat-freak chef on "Friends." Now, it's hard to peg her as just one thing. Besides reprising her role as tabloid reporter Gale Weathers in "Scream 4" (as she did in "Scream 2" and "Scream 3") she stars in the ABC comedy "Cougar Town," and formerly co-executive produced and starred in the FX series "Dirt."
"Scream 4" puts Cox back on screen with David Arquette, the man she met while filming the first "Scream," later married and had a child with. In October, they separated.
Cox told Entertainment Weekly that while things were sometimes awkward on set, she and Arquette are on good terms now.
"I would say we're probably better now than we were during that movie," she said. "The movie was just a little bit of a tough time. I don't have the fondest memories of those particular moments during that film."
In an interview on Howard Stern's radio show Thursday, Cox revealed that Arquette's appetite for sex spoiled their marriage, saying he "could not literally put his arm around me for one second without getting [an erection]."
David Arquette. Arquette scored his most memorable role with "Scream," playing Det. Dewey Riley. After that, his Hollywood endeavors mainly were limited to "Scream's" sequels. Arquette explored the realm of professional wrestling while dabbling in TV projects (he was Cox's co-executive producer on "Dirt") and frequently guesting on Howard Stern's radio show. For the most part, he seemed happy to focus on Cox and their daughter.
That changed in October when Arquette and Cox separated and he spiraled downward, eventually entering a rehab treatment center in January and suffering a car crash in March. Now he's on the mend. Earlier this month, Arquette, 39, celebrated more than 90 days sober by dancing on stage at a concert in Chile.
Neve Campbell. The '90s were good to Campbell: She was a regular in a hit TV show, "Party of Five" and starred in a slew of movies, including playing death-defying Sidney Prescott in the "Scream" series, "The Craft" and "Wild Things."
In the last decade, she's taken on lower-profile projects like the 2004 indie film "When Will I Be Loved," which received rave reviews but had a brief theatrical run. She also divorced her first husband, re-married, and divorced again.