Klein said he had sedated Jackson in the past but only with mild drugs during painful treatments.
"There was nothing wrong with the manner I treated Michael, because what I had to do is restructure for an individual who had lupus, who had terrible acne scarring his face," he said. "But I was not one of the doctors who participated in giving him overdoses of drugs or too much of anything. In fact, I was the one who limited everything, who stopped everything."
But someone apparently was giving Jackson something more powerful, something that could have ended the singer's life.
ABC News has confirmed reports that Jackson's arms were found during the autopsy to be marred with track marks consistent with intravenous use of Diprivan, most commonly used to put hospital patients to sleep in the operating room or an intensive care unit.
Toxicology reports were not due to be released for four to six weeks. The cause of Jackson's death on his death certificate was listed as "deferred."
Klein first met Jackson more than two decades ago and was not just his doctor, but a close friend.
But what he did want to do was set the record straight about some rumors that were very painful to Jackson over the years, including that he purposely lightened his skin so he no longer looked black.
Klein said it was he who diagnosed Jackson with lupus and saw growing evidence of vitiligo, both autoimmune diseases that affect the skin.
"It blew me away because here I'm diagnosing the most famous person in the world ? with a very serious ailment," he said.
As Jackson's skin started to be marked with "severe speckling," Klein said, something had to be done even out the tone.
"At the same time he was in the hands of plastic surgeons who didn't know when to stop," Klein said. "But he felt he was a piece of art, that his face was a piece of art."
Klein said he was stunned by the news of his friend's death, sitting in one spot for hours, saying he "went to almost instantaneous shock."
"I feel horrible for what happened because I really, really love this person, because he was the person who was the consummate entertainer, that could get up on a stage and sing. And once he began entertaining, he ... loved every single person in the audience."