He's tried not to pay attention to the news, but he knows Bishop could face the death penalty.
Anderson was in awe of his wife's brilliance. He said he didn't date much in high school because he never met too many smart girls there.
"I always wanted to have somebody to talk to, to talk with, explore things," he said, adding that his wife liked to do that.
They decided very early that they would have children while they were young and healthy, and he said their main goal was to provide for their children's future, he said.
"You know, a lot of people take out home equity loans for their house … new cars, home improvements. No. In this case, it was only for one purpose, and that was to get four kids through college … of their choice," he said. "If they chose to go to Harvard, we would write that check. And that goal is still there. I will do whatever it takes to make sure these little ladies and my little boy are sheltered and insulated from this as much as possible."
Even though Anderson has met with pastors, he said he still hasn't found any larger meaning to what has happened.
He wants the chance to talk to his wife and ask her himself.
"I just want to go in there and talk to her face-to-face. … I want to know the full story," he said. Meanwhile, he's holding on to his faith.
"They say -- and I believe -- that God is real. He is there," he said. "They say something will come out of this, but at this point … it's very early on. We can't comprehend at this point."
James Anderson met Amy Bishop at a science fiction fan convention, and they hit it off right away.
He remembers that when he asked her out, she replied, "You want to do nothing together?" They spent the day walking around Boston, holding hands.
Their love story progressed to its ultimate conclusion. The couple married and had four children.
This August marks their 20th wedding anniversary, but there's not likely to be a celebration. Amy Bishop sits in jail, charged with fatally shooting three colleagues and seriously injuring three others at the University of Alabama in Huntsville last week.
Anderson can't comprehend it.
Police haven't declared a motive in the shootings that happened at the end of a biology department meeting, but Bishop's associates said she was angry at being denied tenure.
She has been charged with capital murder and attempted murder.
Speaking to "Good Morning America" in a sit-down interview Thursday, Anderson said his wife -- a Harvard-trained researcher and associate biology professor at the university -- had faced a "battle" over securing a tenured position but had other promising job prospects.
On the advice of an attorney, Anderson didn't comment directly on what he thinks happened on Feb. 12.
Anderson's first inkling that something was wrong came when he went to the university Friday to pick up his wife. They had one of their occasional date nights planned for that evening.
"I had pulled up to pick her up to go home. And I thought somebody had gone crazy at the school," the 45-year-old freelance researcher said.
There was a big, chaotic scene, and flashing lights, and his wife was being loaded into a police cruiser. He didn't know why.