He said he didn't realize he was signing a murder confession, which was written in Spanish, even though he speaks some Spanish.
"During the interrogations I was very frightened and confused, and I wanted to leave," van der Sloot said during the interview.
"'If you sign these papers you will be extradited to the Netherlands,' they were telling me all the time. In my blind panic I then signed everything, but I did not even know what was written down," he told the newspaper.
When asked about the murder of Flores, van der Sloot replied, "I have been framed. What happened exactly, I will explain later."
On Monday, he refused to discuss the case with a Peruvian judge.
Anita van der Sloot, whose husband died of a heart attack earlier this year, said she has no more room in her heart for the pain caused by her son.
She has said she won't visit him in jail.
"I can cut certain things off, I can push them away. It's hard but I'm trying to do that," she said. "I just lost my husband and I could not even take the time to mourn about that."
But even as she distances herself from her son, she worries for him.
"Being my son or not, he needs a fair chance of surviving this," she said. "There is also a big chance that he (gets) murdered. There are a lot of people after him. The Joran I know, and his grandma and great-grandma, is a very gentle and sweet Joran, who makes coffee for you, who … will listen to you."
She has previously expressed sorrow for the Flores and Holloway families, and does so again.
"I don't think that words are enough to tell the parents of Natalee Holloway and of Stephany Flores what I feel," she said. "I hope they have a lot of good friends and family members around them that can be for their support. And if they would be here right now, I would cry with them and give them a big hug."