Andrews, 31, was videotaped without her knowledge by a Peeping Tom through a hole in the wall of her hotel room. She was back on camera last week for the first time since the incident for the start of the college football season.
"I'm excited to get back to work," Andrews told Winfrey. "I feel like it's really going to help me heal the wounds."
Also in her premiere week, Winfrey will weigh in for the first time on the death of Michael Jackson and share new details from her 1993 interview with the King of Pop.
"Tell It Like It Is" Dr. Phil McGraw, who became a household name on Winfrey's show, returns on Sept. 17 with the moving story of a woman whose father is a serial killer.
And Friday, Sept. 18, Oprah will broadcast live from "GMA's" home -- New York's Times Square -- with guests Mariah Carey, Regis Philbin and Kelly Ripa.
Watch the new season of "The Oprah Winfrey Show" starting Monday, Sept. 14, and read much more about the new season of Oprah at Oprah.com.