Deep Brain Stimulation Helps Severely Depressed

April 28 -- MONDAY, April 28 (HealthDay News) -- For those with the most severe depression, a novel therapy may offer new hope.

The treatment is deep brain stimulation (DBS), which is used for some people with Parkinson's disease, and researchers found that it cut depression symptoms by 50 percent for about half of those treated.

"This is a new therapy for patients with severe, intractable depression. There's a lot of promise for this approach," said study author Dr. Ali Rezai, director of the Center for Neurological Restoration at the Cleveland Clinic in Ohio.

Deep brain stimulation requires minimally invasive surgery to place electrodes into specific parts of the brain that are believed to be malfunctioning. Once in place, the electrodes emit tiny, adjustable, electrical pulses that block dysfunctional activity in the brain. It's been used for about 20 years in the treatment of Parkinson's disease. Rezai added that the current group working on DBS and depression, which includes researchers from Brown University and Massachusetts General Hospital as well, has also had success using DBS to treat obsessive-compulsive disorder.

Severe depression occurs in about 10 percent to 20 percent of depression cases, according to Rezai. Antidepressants, and even electroconvulsive (ECT) therapy, often fail to bring about improvement in depressive symptoms for those with this severe form, leaving them at an increased risk of suicide. The suicide rate in people with major depression may be as high as 15 percent, according to the researchers.

In the current study, 15 people suffering from severe depression for at least five years who weren't helped by other forms of treatment received DBS implants. Six months later, 47.1 percent had at least a 50 percent reduction in their depressive symptoms, based on a commonly used depression scale. At one year, that number was 50 percent.

Even patients who didn't meet the 50 percent reduction criteria used as an endpoint in this study still experienced some symptom reduction, according to Rezai, who added that all of the participants said they would undergo DBS again.