Popular Antidepressants: How They Stack Up

To rate the 12 antidepressants studied, researchers used two separate measures. The first was efficacy -- or how likely patients were to experience the desired effects of the drug. The second was acceptability -- the likelihood that a patient would continue using a drug for the duration of the study (it is generally assumed that a high ratio of patients dropping out indicates the presence of undesirable side effects for a drug).


1) Mirtazapine (Remeron)

2) Escitalopram (Lexapro)

3) Venlafaxine (Effexor)

4) Sertraline (Zoloft)

5) Citalopram (Celexa)

6) Buproprion (Wellbutrin)

7) Paroxetine (Paxil)

8) Milnacipran (Savella)

9) Fluoxetine (Prozac)

10) Duloxetine (Cymbalta)

11) Fluvoxamine (Luvox)

12) Reboxetine (Vestra)


1) Sertraline (Zoloft)

2) Escitalopram (Lexapro)

3) Buproprion (Wellbutrin)

4) Citalopram (Celexa)

5) Fluoxetine (Prozac)

6) Milnacipran (Savella)

7) Mirtazapine (Remeron)

8) Venlafaxine (Effexor)

9) Paroxetine (Paxil)

10) Duloxetine (Cymbalta)

11) Fluvoxamine (Luvox)

12) Reboxetine (Vestra)

Source: Cipriani et al, "Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis." Lancet (2009).

Join the Discussion
blog comments powered by Disqus
You Might Also Like...
See It, Share It
PHOTO: Year In Pictures
Damien Meyer/AFP/Getty Images
PHOTO: James Franco and Seth Rogen in The Interview.
Ed Araquel/Sony/Columbia Pictures/AP Photo
PHOTO: Patrick Crawford is pictured in this photo from his Facebook page.
Meteorologist Patrick Crawford KCEN/Facebook
PHOTO: George Stinney Jr., the youngest person ever executed in South Carolina, in 1944, is seen in this undated file photo.
South Carolina Department of Archives and History/AP Photo