Losing the White House: Depression Sets In

June 4, 2008 — -- Losing ain't easy — especially after almost a year spent tirelessly campaigning to become the first female president in the nation's history.

Sen. Hillary Clinton, D-N.Y., will likely feel a tremendous sense of disappointment and failure, according to former politicians who also lost their bids for the White House.

"You don't run as hard as we run and lose and feel good about it," former Massachusetts Gov. Michael Dukakis told ABCNEWS.com.

Dukakis, who was the Democratic Party nominee in the 1988 presidential election, eventually lost the election to George H. W. Bush.

Almost two decades later, Dukakis said he still thinks about what might have been.

"These days, I somewhat jokingly say that if I'd beaten the old man [Bush], we'd never have had the kid [current President Bush] and the country wouldn't be in this mess," said Dukakis. "I still feel that responsibility still."

Feelings of nostalgia, sadness and discontent are to be expected as Clinton becomes the latest fatality of the Democratic Party and, much like those who came before her, she will struggle with the question "what if?"

"The disappointment is huge," Dukakis said of his 1988 loss. "I wasn't happy with myself or my performance and certainly not the results."

Carol Dweck, a professor of psychology at Stanford University and the author of "Mindset: The New Psychology of Success," told ABCNEWS.com that feelings like Dukakis' are common among ambitious people who experience failure in their careers.

"It is tremendously disappointing to do everything you're supposed to and work as hard as [Clinton] has and not succeed," said Dweck. "It's a tremendous blow and takes time to recover."

On ABC's "Good Morning America" this morning, Clinton supporter and political commentator James Carville said that losing her bid for the presidency will take time for the senator to process.

"This is a very emotional, human endeavor," said Carville. "A lot of relationships and a lot of dreams and hopes have gone down."

"I would think it's going to take a couple of days to absorb everything," added Carville.

"This thing doesn't have a switch," said Carville. "You don't walk in a room and turn it off and turn another one on."

Dukakis told ABCNEWS.com that while he did not cry following his loss, that may partly have been due to his other responsibilities: Dukakis returned to the work force and reported to his governor's post the day after the election.

"I didn't have much time to sit around and feel sorry for myself," he said. "But there is a disappointment factor and a fatigue factor."