Scientists Create First 'Synthetic' Cells

Scientists Create First Synthetic Cells

In a development that seems likely to stir a firestorm of controversy, researchers said Thursday that they have used genes made in the lab to create a synthetic species of bacteria.

"We're here to announce the first synthetic cell," said J. Craig Venter, head of the self-named J. Craig Venter Institute in Rockville, Md., and leader of one of the teams that decoded the human genome.

He told reporters that the new species -- dubbed Mycoplasma mycoides JCVI-syn1.0 -- is similar to one found in nature, except that the chromosome that controls each cell was created from scratch. The research is reported in the May 20 issue of the journal Science.

The new species, Venter said, started with researchers digitizing the genetic code for the new species on computers, then assembling the nucleotides using "four bottles of chemicals" into sections of DNA. The DNA sections were assembled in yeast cells to form a synthetic chromosome, which was then transferred to a related species of bacteria, M. capricolum.

VIDEO: An organism controlled by completely manmade DNA can grow and reproduce.
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Late in March, the researchers told reporters, the modified cells began replicating and formed a "blue colony" of the new species.

"This is the first self-replicating species that we've had on the planet whose parent is a computer," Venter said.

Indeed, he and his colleagues consistently used computer language to describe the work. The new chromosome is like an operating system, they said, and it reprograms the M. capricolum cells to become M. mycoides.

The result comes after 15 years of research -- and some $40 million -- aimed at finding what Venter has called the minimal genome: the smallest set of genes that can support a living creature. But it could quickly have spinoffs, the researchers said.

Among the possibilities are new tools for vaccine and pharmaceutical development, as well as new biofuels and biochemicals, they said. Venter suggested during the press conference that synthetic algae might be designed to cope with oil spills such as the one currently threatening the Gulf Coast of the United States.

Along with genes needed for life, the researchers added "watermark" DNA sequences to distinguish the synthetic genome from a natural one.

The watermarks include the names of 46 scientists who worked on the project, a website address for the new species, and quotations from author James Joyce and physicist Richard Feynman.

Describing the new species as "synthetic" may be going too far, according to some experts.

It's "synthetic in the sense that its DNA is synthesized, not in that a new life form has been created," according to Jim Collins, professor of Biomedical Engineering at Boston University and an expert in synthetic biology. "Its genome is a stitched-together copy of the DNA of an organism that exists in nature, with a few small tweaks thrown in."

Collins made that observation in a short commentary on the research, one of eight published in the rival journal Nature and released today.

But bioethicist Art Caplan of the University of Pennsylvania, wrote in the commentary that the result is "one of the most important scientific achievements in the history of mankind."

He argued that creating the synthetic genome finally rings the death knell for the notion of vitalism, the idea that there is a life force that distinguishes living matter from the inorganic.

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