Study Knocks Diagnostic Value of Prostate Cancer Screening Test

Share
Copy

Receiver operating characteristic analysis showed minimal improvement in the area under the curve (AUC) when PSA velocity was added to other predictors of prostate cancer risk (AUC 0.702 versus AUC 0.709).

Even less improvement in predictive accuracy was observed for detection of high-grade or clinically significant cancers.

"There was little evidence that PSA velocity adds an important level of predictive accuracy to either standard predictors or to PSA alone," the authors wrote.

"Superior risk stratification can be achieved simply by choosing a different PSA cut point, especially for the endpoints of high-grade cancer or clinically significant cancer," they added.

The Prostate Cancer Prevention Trial used a PSA cutoff of 4.0 ng/mL as a biopsy trigger, resulting in a biopsy rate of approximately one in 20 with no appreciable loss in diagnostic accuracy, Siu-Long Yao, PhD, and Grace L. Lu-Yao, PhD, of the University of Medicine and Dentistry of New Jersey, wrote in an accompanying editorial.

Imperfect Screening Test

The study by Vickers et al. serves as a reminder that "the use of PSA as a screening tool leaves much to be desired," wrote Yao and Lu-Yao. "Indeed, after more than 20 years of PSA screening, it has been estimated that approximately one million men may have been unnecessarily treated for clinically insignificant prostate cancer."

"The shortcomings of PSA testing also remind us that there is still much art to the diagnosis and treatment of prostate cancer."

Page
  • 1
  • |
  • 2
Join the Discussion
You are using an outdated version of Internet Explorer. Please click here to upgrade your browser in order to comment.
blog comments powered by Disqus
 
You Might Also Like...
See It, Share It
PHOTO: U.S. Customs and Border Protection officers at the George Bush Intercontinental Airport in Houston stopped a would be smuggler from bringing nearly 7 ounces of cocaine into the country in tamales, Aug. 22, 2014.
U.S. Customs and Border Protection
Real Housewife Phaedra Parks Lists Home in Suburban Atlanta
Real Housewives of Atlanta star, Phaedra Parks, has listed her 4,000-square-foot home with 5 bedrooms and 6 baths for $340,900.
In this image from video posted on Facebook, courtesy of the George W. Bush Presidential Center, former President George W. Bush participates in the ice bucket challenge with the help of his wife, Laura Bush, in Kennebunkport, Maine.
(Courtesy George W. Bush Presidential Center/AP)