Cytarabine Crisis: Leukemia Drug Shortage Affecting Many Hospitals

ABC News heard from dozens of medical centers on reported shortages of the leukemia drug cytarabine. While some hospitals reported no shortages, others said supplies of the drug were running critically low -- and in some places, shortages have even affected patient care.

Below is a list of the hospitals that responded, as well as quotes from spokespeople for some of these institutions.

Hospitals Where a Cytarabine Shortage Has Affected Patients

Johns Hopkins: Baltimore, Md.

"We were on the verge of rescheduling all patients (adults and pediatric) but we found some... If the present reorder scheduled for this Friday does not come in, we have a two-week supply. Adults have now changed protocols (alternative therapies) -- there were no alternative therapy for pediatric patients, but since we needed less we've been able to keep up. Unfortunately, some pediatric patients are getting adult-size medications. We are really worried if we get a new patient with [leukemia], that will be very hard to keep up with."

Nebraska Medical Center: Ohama, Neb.

"At one point last week we were completely out of enough cytarbine for any new patients. We had enough to finish the current patients we had in the hospital, but no new ones. We have gotten some small shipments since then."

Massachusetts General Hospital, Boston, Mass.

"Absolutely. Major problem."

University Hospital, Cleveland, Ohio

University Hospital said that there are currently four pediatric acute leukemia patients on this drug, but added that it would be difficult to accommodate any more patients on the amount they currently have.

Centura Health: Englewood, Colo.

"We have received three patient referrals from local physicians for the drug. We have enough left for four patients, or about one month."

Tufts Medical Center: Boston, Mass.

"Tufts Medical Center does have a shortage of cytarabine. I have been told that we are working with only 40 grams in stock as of this moment and we needed 110 grams just today. There is no new stock in sight."

University of Alabama Hospital, Birmingham, Ala.

"We're projected to get some drug by the end of the week (hopefully), but we still don't know how much will arrive to the wholesaler and how much is set aside for us. As of today, we should have enough drug in our inventory to last through the week."

Mayo Clinic, Rochester, Minn.

"Yes, we are acutely aware of the issues, have been 'affected' by the shortage and are managing the situation. Mayo has also contacted the FDA, along with other medical institutions, to express extreme concern about these and other shortages."

Ohio State University Comprehensive Cancer Center, Columbus, Ohio

Dr. Joseph Flynn, clinical director of hematologic malignancies at OSUCCC-James said the shortage is an issue that has been ongoing for the past couple of months, and affects patients with not only AML, but also some lymphomas. Currently OSUCCC-James has about a six-week supply on hand, and the hospital's pharmacy manager is contacting supplies and other local hospitals trying to get more of the drug.

University of Chicago, Chicago, Ill.

"[The] cytarabine shortage has critically affected our leukemia clinical trials being run by the CALGB at member institutions across the country. We have been actively trying to negotiate borrowing and sharing of cytarabine between institutions so that patients can stay on schedule with their protocol-directed treatments."

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