11 Baffling Medical Conditions

"We're not really sure of the diagnosis," said Catherine Mancuso, an orthoptist who coordinated Adler's treatment plans at The Royal Victorian Eye and Ear Hospital in Melbourne, Australia.

"There's nothing that would cause symptoms of a woman to close her eyes for three days, and open her eyes for three days," said Dr. Dean Cestari, a neuro-ophthalmologist at the Massachusetts Eye and Ear Infirmary in Boston.

Cestari believes that at least part of Adler's condition may be attributed to a psychological condition that has manifested itself in a physical way.

"It can be hard, because sometimes these patients come in with real experiences. They aren't making this up," said Cestari. "But the mind converted a conflict into a physical manifestation."

For now, Adler receives Botox treatments to the muscles surrounding her eyes. The injections often help her to keep her eyes open, but she said that the effectiveness of the treatments is starting to wane.

Now she is holding out hope for a more permanent solution, as well as a way to continue her day-to-day life despite the condition.

"In the beginning, I tried to ignore it, but [I] have now learnt to live with it," she said.

Persistent Sexual Arousal Syndrome

For those who have never experienced persistent sexual arousal syndrome, or PSAS, its symptoms may seem more like a godsend or a dirty joke than a debilitating condition.

However, for the women who experience PSAS -- which causes them to live perpetually at the brink of orgasm -- the condition is a nightmarish curse. And up until 2001, it was a curse that didn't even have a name.

"I thought I was alone in this," Heather Dearmon, a 34-year-old South Carolina woman who experiences PSAS, told ABC News' "Primetime." "And this is after seeing every kind of doctor imaginable -- gynecologist, psychologist, psychiatrist -- you know, everything. And none had ever heard of anything."

Relief from the condition is often as elusive as sympathy. The sensations, which are not brought about by fantasies or other sexual thoughts, are often only partially relieved through orgasm. For some women, even sex does not help quell their arousal, and on occasion can even make the sensations worse.

Dr. Irwin Goldstein, a professor of surgery at U.C. San Diego and the head of the Sexual Health Program at Alvarado Hospital, studies the condition and says understanding of it is spare, even within the medical community.

"Every lecture I give on this, there's always smirks in the audience: 'Oh, I wish my wife was like this.' These are professional physicians," Goldstein said. "And I said, 'No, no, you're, you don't really want this. You do not want your wife to have this, please.'"

Indeed, the mortifying nature of PSAS leads Goldstein to believe that perhaps thousands of women suffer from the condition without seeking a doctor's help.

"To me this is a sickness," Dearmon said. "This is not, it's not something we've chosen. ... I would rather never have another orgasm in my life for the rest of my life than to have this problem."

The Man Who Never Gets Cold

Wim Hof, 49, of the Netherlands, possesses such a strong resistance to cold that scientists remain baffled as to how he endures many of the tests to which he exposes his body.

The Guinness world record holder has immersed himself, nearly naked, in ice for one hour and 12 minutes.

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