Amelia's younger sister was just 15 months old last November when she, too, developed juvenile arthritis. Like her sister, she had painful joints; both stopped growing. Just recently, Liberty has developed inflammation in her right eye related to her arthritis and takes drops six to eight times a day. Untreated the condition, uveitis, can cause blindness.
"One day in the tub I saw that one knee was way bigger than the other knee, but I thought there is no way possible I would have two kids with it," said Schultz. So far Liberty is "in better shape" than Amelia. The family has a son, 7, who shows no signs of arthritis.
Both girls had tried anti-inflammatory and steroid medications, often the first line of defense for treating arthritis.
In the last decade, there have been significant advances in the treatment of arthritis, especially for those who do not respond to conventional drugs. The most important has been the development of a group of drugs called biologic response modifiers or biologics.
Now, like Campbell Pruden, the girls these biologics, known as TNF (tumor necrosis factor) inhibitors that suppress the inflammatory response seen in arthritis.
So far, neither of the Schultz girls has any joint deterioration. But their mother worries about potential side effects with these powerful biological medicines -- one of them lymphoma.
"It's scary," she said. "But we don't have a choice. Years ago kids were in wheelchairs and crippled. Now, with the medicines, you wouldn't be able to tell they have arthritis."
As for Campbell Pruden, she is now in a "holding pattern," doing well as doctors have cut back on her medications. Her parents keep her off red meat and dairy, part of an anti-inflammation diet.
"She can have some sort of remission, but it will be in her body for the rest of her life," said Pruden. "You never know when there is going to be a flair up. Right now, we just hope it stays dormant.
Nowadays, Campbell joins her parents hiking and on other outdoor activities. "She's a trooper and wants to do everything we do," said her mother.
Just recently Campbell got a fever and her parents worried she was taking a downward turn. "Doctors ruled out a flair-up [of her arthritis] -- it was an early version of the flu," said Pruden. "If it's flu, I'll take it."
The Prudens' greatest reward comes from helping others with the disease.
"I make it my mission to raise awareness," she said. "These children live in pain every day and can't even wake up and go to school because of the pain in their body. We need to find a cure, to find a way for these kids to lead strong, happy lives."