Knox smiled at her family as she entered court, looking a little less tense than in recent days when the prosecution was making its case against her and depicting her as the knife-wielding mastermind of the murder.
Today was the first day of closing arguments for the defense, which began with Luca Maori, one of two lawyers for Raffaele Sollecito.
Maori placed the responsibility for the crime squarely on Rudy Guede, and then spent six hours rebutting the evidence presented against Sollecito by the prosecution.
"We already have the guilty person," Maori told the court, "and that is Rudy Guede. The DNA is his, as are the fingerprints, and the footprints," Maori said.
Maori defended Sollecito's character, saying he is a person friends describe as a "quiet, shy and romantic" young man.
Sollecito "is the second victim in this affair," Maori told the court.
Sollecito's lawyer meticulously reviewed the evidence and witness testimony presented by the prosecution, including the two main pieces of evidence investigators say put him on the scene of the crime: his DNA on the victim's bra hook and a bloody footprint police say is compatible with his foot.
He reiterated what was said repeatedly in the course of the trial: that the DNA on the bra is probably due to contaminated evidence, and the footprint, according to Maori, belongs to Guede.
Maori also introduced a new bit of evidence he says defense experts discovered: a biological substance visible on the pillow found in the victim's room, which Maori's experts believe to be semen. He said the substance was never tested by the forensic police.
"Why were the two spots visible on the pillow found under the victim not tested?" Maori asked when speaking to journalists outside the courtroom. "The crime against Kercher was sexual," Maori added, "but no one tested those stains."
In the course of the trial, investigators said no semen was found on the scene of the crime, though injuries to the victim, and the fact that she was found naked from the waist up, indicated she had been sexually assaulted. Rudy Guede's DNA was found on Kercher's body.
The trial resumes on Monday, and lawyers for Knox will make their case in closing arguments Dec. 1 and Dec. 2.
A verdict is expected on Dec. 4 or Dec. 5.