Her worldwide run is in aid of the Prostate Cancer Charity, as well as the Siberian Railway Cancer Hospital at Omsk, the Kitezh Children's Community orphanage and the Nepal Trust.
"Rosie's aim is not just to raise money, but to increase the profile of cancer awareness, especially of the importance of early screening for cancer," her press agent, Sallyanne Sweeney, told ABC News.
Pope sees this trip as one of many.
The seasoned traveler sailed solo across the Atlantic in 1983, and even gave birth to her son, James, on a round-the-world sailing trip. James is now 37, two years younger than sister Eve. Pope has two grandchildren.
Undeterred by her lengthy time away — the trip took more than twice her prediction of two years — Pope evidently thrives on adventure. "Everyone says I look better than ever after my trip," she said.
In the coming months, Pope will spend some time in Wales with her family, while giving talks and writing a book about an adventure she deems as serious as going to Mount Everest.
In the meantime, she is happy to discuss her round-the-world run with anyone curious enough to ask. "It is interest and publicity that helps to save lives," she said.