Last week, Knox took the stand in her own defense for nearly 12 hours over two days, initially speaking in English but switching to Italian after appearing frustrated with her translator. After 18 months in prison, Knox is fluent in Italian.
Despite months of hearing prosecution witnesses presenting evidence against her, Knox appeared calm and confident on the stand, claiming she stayed at her boyfriend's house all night the evening her roommate was murdered.
She also claimed she had been pressured and beaten by authorities, citing the allegedly harsh police tactics as the reason she gave statements early in the case that she now says were false.
Mellas has said she thought her daughter did well, and that she was pleased with the testimony.
Mellas was greeted by a frenzy of media from around the world who asked her, Who is Amanda Knox?
For the past year and a half, Knox has been a media sensation, dubbed "the angel face with icy blue eyes," her life publicly dissected.
All along, Knox's family has refuted media reports that she was a sex-crazed killer, saying the portrayal of her could not be further from the soccer-playing, academically minded daughter they raised.
Last week, Knox testified that she was shocked by the death of Kercher, a woman she considered a friend, and elaborated on her claims of mistreatment by police.
Tensions rose in the courtroom as lead prosecutor Guiliano Mignini accused Knox of evading his questions and the judge had to chide her to respond.
"I was very, very scared," Knox testified, "because they were treating me so badly and I didn't understand why."
When the prosecution grilled Knox on who hit her, she said she didn't know her name -- just that it was a policewoman with long, brown hair.
Mignini asked Knox why she would sign a statement that wasn't true, and she answered, "They kept saying I was either a stupid liar or I forgot."
"I was so scared and so upset at that point," she said. "I thought, 'Gosh, maybe they're right, maybe I did forget.'"
Her father, Curt Knox, said he was very proud of his daughter.
"We were able to go behind the wall, I call it, and actually hug her and tell her that she did really good," he said. "I mean, she was very articulate. She answered all the questions. I think she cleared up a number of things."
The defense is expected to start attacking the prosecution's forensic evidence from the crime scene.
A verdict is expected in the fall. Knox faces life in prison if convicted.