Along the way, he gives back to the community in which he was raised. He funded a community garden through Bette Midler's New York Restoration Project.
"Bette's got the greenest thumb in New York City," he said, leading a tour of the garden. A woman working there caught his eye. "Come give me my hug," he told her. "She looks after the garden."
He's focusing on new ventures, including cologne. And he co-wrote a new self-help book, "The 50th Law." The book is a primer on overcoming fear and flexing one's power.
He takes the show-no-fear ethos of the book seriously.
But he admits to having weaknesses, although he's not sharing.
"Why would I tell them?" he said.
He bought his mansion, he said, from the former wife of Mike Tyson, despite a tangled web of interpersonal connections.
It turns out that the gunman who shot 50 Cent nine times was Tyson's friend.
"He previously was friends with him," the rapper said. "Where I'm from, my friends kind of killed my friends before in different situations, so it doesn't feel like anything personal."
It's a stark reality for him. "Well, the world is cold, man," he said.
His view of the world is reflected in his love life. His former girlfriend, the mother of his only child -- a son named Marquise -- sued him for $50 million. When she lost the case, 50 Cent said, she started restricting his access to the child.
It was frustrating for him, he said, as someone who has struggled psychologically from not having a dad around to not being able to see his son.
"But he knows I love him," he said.
Despite the time he spends alone, 50 Cent said he's not lonely. "I'm content with where I'm at. I'm not trying to get your sympathy," he said. "The guy that sits there and says. 'I'm lonely' in the middle of being one of the most popular people around, it translates into he wants some sympathy in some way."
He doesn't mind rattling around in a huge house by himself.
"Yeah, it's fun like that," he said.
He talked about the prospect of settling down someday. "Maybe" he would get married, he said -- but only maybe.
"Well, you got 53 percent of people getting divorced in this climate," he said. "I think marriage and some of those things [are] turning into a business deal. When you got to go to your attorney and go to her attorney and negotiate what the prenup is and if you have three kids, you're going to get this much money, three more years going to pay you this much.
"Doesn't it sound like deal points?"