"I went to Darfur [Sudan] and Tanzania for two weeks the first trip I made, and it just changed me, wrecked me. I was a different person when I came back," she said. "I talked to my mum for three hours."
"I had to present something at an awards ceremony two weeks later, and I was sure, I thought I'm going to go on, I'm just going to hate this. I'm going to think everybody is false and shallow."
But Jolie says her experience in refugee camps makes her more empathetic to those around her.
"I ended up seeing all the people on the red carpet as: 'God, they must have just spent hours trying to put themselves together and their kids are maybe watching.' I just felt for everybody in the room."
She appreciates the power of her celebrity and acknowledges that it gives her more influence in her advocacy work.
"The part of me that would like to just become a field officer tomorrow knows that I can do more good with one foot on one side, and one foot on the other."
Jolie is pregnant and has two adopted children -- Maddox, 4, and Zahara, 1. She said she would like to have "lots of babies."
"I'd love to adopt just a bunch more kids, have a few, and, just be traveling, be home, or, you know, not working the next few months," she said. "I haven't worked much this year, and it's been really nice."