He appeared afterwards on a huge plasma screen, waving to Michelle and Malia, 10, and Sasha, 7, who came out to hug their mother after her speech.
The little girls stole the show afterwards peppering their father with questions, "What city are you in, Daddy?"
"I love you Daddy!" they yelled at him.
Going into the convention, Michelle Obama faced pressure having been the target by some Republicans early on in the Democratic primaries, her patriotism questioned especially over remarks she made after her husband won the Iowa Caucuses.
"For the first time in my adult lifetime I'm really proud of my country," she said speaking to a Democratic rally in Milwaukee, Wisc., Feb 18. A flood of criticism followed the remark, especially from conservative talk radio hosts and bloggers.
But on Monday night, the former corporate lawyer and medical center executive choose her words carefully, with a speech for which she wrote several drafts including a full draft completed as early as two weeks ago, a senior Obama campaign official told ABC News.
"I come here as a wife who loves my husband and believes he will be an extraordinary president," Michelle Obama said.
Michelle Obama opened the door a bit on the Obamas 16-year marriage and described what makes their relationship click.
"In the end, after all that's happened these past 19 months, the Barack Obama I know today is the same man I fell in love with 19 years ago," she said.
"He's the same man who drove me and our new baby daughter home from the hospital ten years ago this summer, inching along at a snail's pace, peering anxiously at us in the rear view mirror, feeling the whole weight of her future in his hands, determined to give her everything he'd struggled so hard for himself, determined to give her what he never had: the affirming embrace of a father's love."
In an emotionally charged high point of the evening, Kennedy took the stage smiling and waving as a huge swell of applause went up in the convention hall.
"Nothing, nothing is going to keep me away from this special gathering tonight," Kennedy said to wild applause and cheers.
Television cameras panned to Kennedy's niece, California First Lady Maria Shriver, who wiped away tears from her face as she listened.
"And this November, the torch will be passed again to a new generation of Americans. So with Barack Obama and for you, our country will be committed to his cause. The work begins anew, the hope rises again, the dream lives on."
On the convention floor of Denver's Pepsi Center, Obama campaign volunteers in fluorescent yellow vests distributed "Change We Can Believe In" signs to delegates cheering the Monday night line up of Democratic stars.
Hollywood stars, too, roamed among the delegates on the convention floor between the speeches, including director Spike Lee.
Caroline Kennedy introduced a moving video tribute to her uncle, the long-serving Democratic senator, and compared Obama to him and her father, John F. Kennedy.
"Leaders like them come along rarely. But once or twice in a lifetime, they come along just when we need them the most. This is one of those moments," she is expected to say according to released remarks.
"I have never had someone inspire me the way people tell me my father inspired them, but I do now, Barack Obama."