Clinton, speaking on "GMA," noted McCain's efforts to tone down the anger among his supporters.
"I think they've been negative, but I think Sen. McCain himself has publicly said that's not the direction he wants to go, and I appreciate that," she said.
McCain has made appeals to his audiences in recent days that they confront Obama's candidacy with respect, arguing that Obama is a "decent family man."
For McCain to win next month, he will have to do what no other presidential candidate has ever done -- come back from a 10-point deficit with only three weeks to go.
"No candidate has ever lost with a lead like this since modern polling began in 1936," ABC News' senior Washington correspondent George Stephanopoulos told "GMA."
Stephanopoulos said Obama's candidacy is riding a surge of public opinion, fueled by the current economic crisis, which is devastating for the Republicans.
A record number 90 percent of Americans feel the country is on the wrong track and 73 percent disapprove of President Bush's performance, according to the ABC/Post poll.
That disapproval number is also a record, and because Bush is a Republican, it makes it harder for McCain, the GOP candidate, to argue that he would be best to handle the economy.