Obama campaign manager David Axelrod added the comment was "part of an insidious pattern that needs to be addressed" within the Clinton campaign, pointing to Clinton's remark to 60 Minutes that rumors Obama is a Muslim aren't true, "as far as I know," she said.
"When you wink and nod at offensive statements, you're really sending a signal to your supporters that anything goes," Axelrod said, arguing Clinton is seen as a "divisive and polarizing force."
The Obama campaign pounced Tuesday afternoon on Clinton's mild statement about Ferraro's remark, referring to language Clinton herself used when she urged Obama to denounce and reject anti-Semitic comments by Nation of Islam head Louis Farrakhan.
"With Senator Clinton's refusal to denounce or reject Ms. Ferraro, she has once again proven that her campaign gets to live by its own rules and its own double standard, and will only decry offensive comments when it's politically advantageous to Senator Clinton," Obama campaign spokesman Bill Burton said.
"Her refusal to take responsibility for her own supporter's remarks is exactly the kind of tactic that feeds the American people's cynicism about politics today and it's why Barack Obama's message of change has resonated so strongly in every corner of the country," Burton said.
Ferraro, currently a lobbyist in New York with Blank Rome Government Relations, did not return ABC News requests for comment. She is expected to appear on ABC News "Good Morning America" Wednesday.
It's not the first time a Democratic surrogate has made controversial remarks.
Obama's senior economic adviser Austan Goolsbee told Canadian diplomats the candidate's anti-NAFTA rhetoric should be interpreted as political positioning and not an articulation of policy, according to a Canadian government memo.
Obama foreign policy adviser Susan Rice was part of a mini-firestorm last week when she appeared to go off message and said that neither Obama nor Clinton is ready to answer the proverbial 3 a.m. phone call in the White House.
"Clinton hasn't had to answer the phone at three o'clock in the morning and yet she attacked Barack Obama for not being ready. They're both not ready to have that 3 a.m. phone call," Rice told MSNBC last week.
At the time, the Clinton campaign e-mailed a YouTube video of the interview to reporters.
Earlier in the campaign, Bill Shaheen, a Clinton campaign co-chairman in New Hampshire, stepped aside after making remarks about Obama's past drug use. The Clinton campaign also fired Iowa staffers who forwarded e-mails with false rumors that Obama is a Muslim.
Ferraro's comments appeared to highlight her frustration with Obama's campaign. The Illinois senator is leading Clinton in popular support and pledged delegates, according to ABC News' delegate scorecard.
In the interview with the newspaper, Ferraro also rejected the notion that Obama will bring together Republicans and Democrats.
"I was reading an article that said young Republicans are out there campaigning for Obama because they believe he's going to be able to put an end to partisanship," Ferraro said. "Dear God! Anyone that has worked in the Congress knows that for over 200 years this country has had partisanship — that's the way our country is."
In February, Ferraro made similarly racially-charged remarks on Fox News Radio's John Gibson show.