Clinton leaves office on a new high in personal popularity and broad approval of her work as secretary of state.
A Washington Post/ABC News poll released Dec. 6 shows 57 percent of participants saying they'd back a run by Clinton to succeed President Obama.
Asked about his wife's Oval Office ambitions last April, Bill Clinton said he would be happy either way.
"If she comes home and we do this foundation stuff the rest of our lives, I'll be happy. If she changes her mind and decides to run, I'll be happy," the former president said. "But that's light-years away."
He said he thought Hillary was being honest when she said she would not run again, but "it's entirely up to her."
"I want her to do what she wants to do," Clinton said. "I'm glad she's comin' home, I miss her. We have fun together."
Clinton has traveled almost 1 million miles and spent 401 days of her four years traveling, according to the State Department.
Her last weeks in office have not reflected the prolific nature of her travels throughout her tenure. A case of the flu and a bad concussion kept Secretary Clinton ground-bound, forcing her to cancel a trip to the Middle East and preventing her from testifying about a report to Congress about the State Department's failure to provide adequate security in Benghazi.
Clinton released a statement on Friday thanking her staff and congratulating Sen. John Kerry.
"The men and women of the State Department and USAID represent the best traditions of a bold and generous nation. They serve and sacrifice every day, often in dangerous circumstances. It has been one of the great honors of my life to serve with such fine public servants over the past four years. I could not be prouder of all we have achieved together," Clinton wrote in the statement. "They deserve the highest caliber leadership, and that is exactly what they'll get in John Kerry."