But perhaps more remarkable than their matriculation to two of the nation's finest private schools is that they pursued their expensive, self-financed degrees without any guarantee they'd lead to jobs in the country they called home.
Felix and Tran died in a tragic car accident in May, shortly after their interview with ABC News. But friends say the duo's desire to defy the odds lingers as an example of the immigrant spirit they say has gone largely unnoticed in American society.
"Their courage, their determination, their spirit were an inspiration to us all," said UCLA professor Kent Wong, who taught the two students as undergraduates.
Tran, an aspiring filmmaker, pursued a Ph.D. in American civilization at Brown University. Felix, who dreamed of being a doctor in her East Los Angeles community, was studying at Columbia University's Mailman School of Public Health.
"I always ask myself is it worth it," Felix said of her pursuit of a master's degree in an interview several months before her death. "You can graduate from college with your degree, but your degree isn't worth anything because you don't have a nine-digit [Social Security] number that shows you can work."
She said her seemingly irrational goal was about more than money, however: it was a chance to defy the stereotype of illegal immigrants as "unmotivated and uneducated."
"I knew if I got accepted to an Ivy League school, it's showing the government and people who have anti-immigrant sentiment and all that that, hey, I'm here working really hard and I deserve for them to give me an opportunity because I've been very successful," she said.
Felix was brought to the United States by her Mexican parents as a teenager and grew up in the Los Angeles suburbs, one of an untold number of undocumented immigrant students who have been pressing Congress for a path to legal residency and easier access to higher education.
A number of legislative proposals in both the House and Senate, including the so-called Dream Act, would extend relief to students who arrived in the U.S. as adolescents, completed their degrees and have no criminal record. But election-year political pressures and a packed agenda have so far stalled consideration of the bills.
An estimated 65,000 undocumented immigrants graduate from U.S. public high schools every year, according to the Urban Institute. Some later attend public or private colleges and universities.
State and federal law does not restrict immigrants from attending college or require proof of citizenship for enrollment, but some state universities and private institutions have deemed undocumented residents ineligible for lower, in-state tuition rates and financial aid.
"We're supposed to provide in-state tuition and green cards to people who broke the law and have no right to be in the country?" questioned Dan Stein, president of the Federation for American Immigration Reform, which supports limits on undocumented students in U.S. schools.
"These kids are citizens of other countries, and they could go back to that country and get an education there at taxpayers' expense," he said.