After close to 30 seconds of standing applause, Biden thanked the crowd.
“I’m the least qualified man here tonight, thank you,” Biden said.
While introducing Lady Gaga to sing her nominated song “Til It Happens To You” from the documentary “The Hunting Ground,” Biden asked the audience and those watching the show to sign on to the pledge at the "It’s On Us" website.
“Let’s change the culture,” Biden said. “We must and we can change the culture so that no abused woman or man like the survivors here tonight ever have to ask themselves, ‘What did I do?’”
Earlier in the day, the vice president's office launched a new "behind-the-scenes" Twitter account for Biden. It also urged followers to sign onto the pledge at ItsOnUs.org.