Biden, a six-time U.S. senator who is instrumental in the administration's health care reform strategy and advising the president on matters of foreign relations, potentially could speak to a wide range of political issues.
He last appeared on the show in 2007 as a senator while promoting his book "Promises to Keep: On Life and Politics," when he called the hostesses "tough" and joked that he had hoped they would ask him about his "booty."
"The View's" "Red, White & View" campaign is an example of how the show has established itself as a player in the American political process.
In 1973, Biden, 29 at the time, became one of the youngest lawmakers ever elected to Congress. Just prior to being sworn in that year, his wife and year-old daughter was killed in a car accident.
He remarried in 1977 and served 36 years in the Senate representing Delaware, 17 as chairman or ranking member of the judiciary and foreign relations committees.
Known as a verbose speaker, Biden has earned a reputation for his often colorful gaffes.
Last month, as President Obama announced the historic passage of the health care reform bill, Biden congratulated the president, whispering "this is a big f***ing deal" within inches of an open microphone.
That same month on St. Patrick's Day, the vice president offered his condolences to the Prime Minister of Ireland, asking that God bless the soul of his still-very-much-alive mother.
Perhaps Biden's most famous gaffe occurred during the run-up to the 2008 presidential election when the Delaware senator, then a candidate for Democratic nomination himself, called his would-be boss and fellow candidate, then-Sen. Barack Obama, "articulate and bright and clean and a nice-looking."
"The View" has become a venue for politicians and candidates alike to face the music, with previous guests including President Barack Obama, President Bill Clinton, Sen. John McCain, R-Ariz., former Republican presidential candidate Mitt Romney and Secretary of State Hillary Clinton.