But Reid has the Democratic registration advantage and a bigger "Get Out The Vote" campaign effort.
"It's really difficult to get a handle on what's going on out there, and it's going to depend almost entirely on the turnout," said Nevada political analyst Jon Ralston. "If the Democrats can turn out a reasonable number of voters, Reid has a chance. But if, in the end, he's so swamped by the enthusiasm among Republican voters, he's going to lose."
Reid's campaign mostly has focused on attacking what it characterizes as Angle's radical views, unearthing old sound bites from the conservative candidate saying she's not in the business of job creation and calling for "Second Amendment remedies."
"She's certainly extreme," Reid told ABC News today. "Anyone that wants to talk about Medicare being unconstitutional ... anyone that wants to talk about abolishing, phasing out, killing Social Security is a little extreme.
"The one thing I think is interesting that she never talks about," Reid said, "is the fact that she complains about the health insurance reform we did, but she never mentions that she is a person who receives through her husband a federal pension."
More recently, Reid's campaign has attempted to turn the attention toward Reid himself, portraying the senator as an experienced lawmaker who will bring back money to the state for economic projects.
Angle, on the other hand, is riding the anti-incumbent wave. She has blasted Reid on taxes, spending, supporting President Obama's stimulus plan and even using taxpayer money to pay for Viagra for child molesters and sex offenders.
Angle, however, has been dogged with controversy since even before she won the primary. Most recently, she was called out for suggesting that sharia law is taking hold in Dearborn, Mich., and Frankford, Texas. Dearborn is governed by the U.S. Constitution and the town of Frankford was annexed by Dallas in 1975.
Republicans cite Angle's whopping fundraising figures as a sign of her popularity and say the Tea Party-favored candidate shouldn't be discounted.
Angle, buoyed by national Tea Parties, beat former state Republican chairwoman Sue Lowden in the primaries in an upset that stunned the Republican establishment.
But Republicans threw their full support behind her in what they see as a chance to topple the Senate majority leader in a replay of 2004, when Republicans regained majority in the Senate by defeating Tom Daschle.
Danny Tarkanian, who also ran against Angle in the Republican primary but now supports the GOP candidate, said Angle's challenge will be to focus on issues where she can hit Reid's record.
"The race is about Harry Reid and the economy," Tarkanian said. "Sharron's objective has got to be to keep the focus away from her and on Reid and the economy. And if she does, she'll be in great shape."
Reid has stepped up campaign events in recent weeks, bringing Democratic bigwigs like former President Bill Clinton and President Obama to Nevada.
Both are needed to energize Democrats. In a climate where enthusiasm within the party is relatively low, that push will help.
"They're coming out for one reason and one reason only, and that's to energize the base turnout, which Reid needs," Ralston said. "He needs to bridge that enthusiasm gap. He needs veteran Democratic voters to turn out, that there's a perceived and a real lack of enthusiasm for the Democratic ticket. So yes, he needs that help."
Clinton rallied the crowd for Reid Tuesday night, and Obama will make his third trip to Nevada next week to attend a rally for the majority leader.