After the buzzer sounded, the Bears players formed a circle on the sideline and danced. In the middle was guard Kevin Canevari, a Charlotte native who's one of the seven seniors on the roster.
"We were confident all week," Canevari said. "We don't really look at it like we're an underdog in this tournament. Obviously, everyone's a great team, there's already been so many upsets."
White finished with 13 points, and A-Sun player of the year Langston Hall and Ike Nwamu added 11 apiece for Mercer.
Watching Florida Gulf Coast upset Georgetown and San Diego State last year gave the Bears an offseason's worth of fuel. Hoffman said his players "worked harder than any team in the country individually to get a chance to get back to the same moment."
Mercer has 1,176 wins as a program -- only 191 more than Krzyzewski has all by himself.
Parker, one of a long list of high school All-Americans on Coach K's roster, finished what might have been his final college game with 14 points.
After the game, however, he told Andy Katz of ESPN.com that his career is incomplete and that could affect his decision about whether to return to Duke for another season. He then added that the emotion of this loss could sway him.
Hood -- a redshirt sophomore who also could be headed to the pros -- had just six points.
Duke has been to 11 Final Fours and has four national titles under Krzyzewski, but his Blue Devils have lost their first tournament game five times.
Just 3.3 percent out of the 11 million-plus brackets submitted to ESPN's Tournament Challenge correctly picked Mercer to upset Duke. And only 66 perfect brackets remain through 20 games of the Round of 64.
Meanwhile, 20.9 percent of brackets had Duke in the Final Four, with 5.3 percent of them winning the national title.
Two years ago, C.J. McCollum and 15th-seeded Lehigh sent the Blue Devils packing 75-70 in Greensboro.
Lehigh's athletic department took to Twitter on Friday afternoon to congratulate Mercer.
Information from The Associated Press contributed to this report.